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Invitrogen™ ATG3 Recombinant Rabbit Monoclonal Antibody (5D2W0)
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Catalog No. PIMA535312
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PIMA535312 100 μL
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Catalog No. PIMA535312 Supplier Invitrogen™ Supplier No. MA535312
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Description

Rabbit Recombinant Monoclonal Antibody

Immunogen sequence: MQNVINTVKG KALEVAEYLT PVLKESKFKE TGVITPEEFV AAGDHLVHHC PTWQWATGEE LKVKAYLPTG KQFLVTKNVP CYKRCKQMEY SDELEAIIEE.

ATG3 (APG3) is a widely expressed conjugating enzyme for APG8 lipidation, an essential step for the initiation of autophagy. Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. Autophagy is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1. ATG3 functions as an E2-like enzyme during the initial stages of autophagosome formation by catalyzing the formation of the Atg8-phosphatidylethanolamine (Atg8-PE) conjugate, which is critical for autophagy.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ATG3
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot
Classification Recombinant Monoclonal
Clone 5D2W0
Concentration 0.23 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene ATG3
Gene Accession No. Q6AZ50, Q9CPX6, Q9NT62
Gene Alias 2610016C12Rik; APG3; Apg3l; APG3-like; Apg3p; atg3; ATG3 autophagy related 3 homolog; atg3.S; Atg3l; autophagy related 3; autophagy related 3 S homeolog; autophagy-related 3; autophagy-related protein 3; DKFZp564M1178; EGK_11288; FLJ22125; hApg3; MGC15201; PC3-96; Pig1; PIG-1; preconditioning-inducible gene 1 protein; Protein PC3-96; Ubiquitin-like-conjugating enzyme ATG3; XELAEV_18014721mg
Gene Symbols ATG3
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Apg3 (Atg3) (Q9NT62).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 171415, 64422, 67841
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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