ATG3 Monoclonal Antibody (OTI3C6), TrueMAB™, OriGene

Catalog No.	Quantity
50-167-4230	100 μL
50-254-0991	30 μL

Catalog No. 50-167-4230 Supplier OriGene Supplier No. TA503301

Description

Mouse Monoclonal Antibody

ATG3 (APG3) is a widely expressed conjugating enzyme for APG8 lipidation, an essential step for the initiation of autophagy. Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. Autophagy is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1. ATG3 functions as an E2-like enzyme during the initial stages of autophagosome formation by catalyzing the formation of the Atg8-phosphatidylethanolamine (Atg8-PE) conjugate, which is critical for autophagy.

Specifications

• Antigen: ATG3
• Applications: Flow Cytometry, Immunocytochemistry, Immunofluorescence, Western Blot
• Classification: Monoclonal
• Clone: OTI3C6
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene: ATG3
• Gene Accession No.: Q6AZ50, Q9NT62
• Gene Alias: APG3, APG3-LIKE, APG3L, PC3-96
• Gene Symbols: ATG3
• Host Species: Mouse
• Immunogen: Full length human recombit protein of human ATG3 produced in HEK293T cell.
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 171415, 478564, 64422
• Target Species: Canine, Human, Rat
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG2a