ATG3 Mouse anti-Canine, Human, Mouse, Rat, Clone: OTI3H2, liquid, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene TA503346

Catalog No. 50-167-4266

Description

ATG3 (APG3) is a widely expressed conjugating enzyme for APG8 lipidation, an essential step for the initiation of autophagy. Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. Autophagy is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1. ATG3 functions as an E2-like enzyme during the initial stages of autophagosome formation by catalyzing the formation of the Atg8-phosphatidylethanolamine (Atg8-PE) conjugate, which is critical for autophagy.

Specifications

• Antigen: ATG3
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: ATG3
• Gene Alias: APG3, APG3-LIKE, APG3L, PC3-96
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 171415, 478564, 64422, 67841
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI3H2
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: Q6AZ50, Q9CPX6, Q9NT62
• Gene Symbols: ATG3
• Immunogen: Full length human recombit protein of human ATG3 produced in HEK293T cell.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Canine, Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG2a