Invitrogen™ ATG3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA517018

Catalog No. PIPA517018

Description

It is not recommended to aliquot this antibody.

ATG3 (APG3) is a widely expressed conjugating enzyme for APG8 lipidation, an essential step for the initiation of autophagy. Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. Autophagy is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1. ATG3 functions as an E2-like enzyme during the initial stages of autophagosome formation by catalyzing the formation of the Atg8-phosphatidylethanolamine (Atg8-PE) conjugate, which is critical for autophagy.

Specifications

• Antigen: ATG3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ATG3
• Gene Alias: 2610016C12Rik; APG3; Apg3l; APG3-like; Apg3p; atg3; ATG3 autophagy related 3 homolog; atg3.S; Atg3l; autophagy related 3; autophagy related 3 S homeolog; autophagy-related 3; autophagy-related protein 3; DKFZp564M1178; EGK_11288; FLJ22125; hApg3; MGC15201; PC3-96; Pig1; PIG-1; preconditioning-inducible gene 1 protein; Protein PC3-96; Ubiquitin-like-conjugating enzyme ATG3; XELAEV_18014721mg
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 171415, 418369, 443885, 478564, 508571, 64422, 67841
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 29 μg/mL
• Formulation: 0.01M HEPES with 100μg/mL BSA, 50% glycerol, 0.15M NaCl and no preservative; pH 7.5
• Gene Accession No.: Q0VCL3, Q6AZ50, Q6GQE7, Q9CPX6, Q9NT62
• Gene Symbols: ATG3, atg3.S
• Immunogen: Synthetic peptide corresponding to residues near the amino terminus of Atg3.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat, Canine, Monkey, Bovine, Chicken, Frog
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov