ATG4B Mouse anti-Human, Clone: OTI1A3, liquid, TrueMAB™

Catalog No.	Quantity
50-168-3246	100 μL

Catalog No. 50-168-3246 Supplier OriGene Supplier No. TA810189

Description

Mouse Monoclonal Antibody

Cysteine protease ATG4b is an enzyme which is coded by ATG4b gene. Autophagy is a critical cellular homeostatic process that controls the turnover of damaged organelles and protein. ATG4bis a deubiquitin-like protease that plays dual roles in the core machinery of autophagy. ATG4b, cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3, GABARAPL1, GABARAPL2 and GABARAP, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. ATG4b is mainly expressed in the skeletal muscle, brain, heart, liver and pancreas.

Specifications

• Antigen: ATG4B
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Classification: Monoclonal
• Clone: OTI1A3
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene: ATG4B
• Gene Accession No.: Q9Y4P1
• Gene Alias: APG4B, AUTL1
• Gene Symbols: ATG4B
• Host Species: Mouse
• Immunogen: Full length human recombit protein of human ATG4B produced in HEK293T Cell.
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 23192
• Target Species: Human
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG2b