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Invitrogen™ ATG4B Polyclonal Antibody
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Catalog No. 01670548
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Catalog No. Quantity
01-670-548 100 μL
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Catalog No. 01-670-548 Supplier Invitrogen™ Supplier No. PA118295
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Description

Rabbit Polyclonal Antibody

Reconstitute in 100 μL of sterile water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20 °C for a higher stability, and at 4 °C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.

Cysteine protease ATG4b is an enzyme which is coded by ATG4b gene. Autophagy is a critical cellular homeostatic process that controls the turnover of damaged organelles and protein. ATG4bis a deubiquitin-like protease that plays dual roles in the core machinery of autophagy. ATG4b, cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3, GABARAPL1, GABARAPL2 and GABARAP, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. ATG4b is mainly expressed in the skeletal muscle, brain, heart, liver and pancreas.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ATG4B
Applications Immunohistochemistry (Frozen), Western Blot
Classification Polyclonal
Concentration Conc. Not Determined
Conjugate Unconjugated
Formulation whole serum with no preservative
Gene Atg4b
Gene Accession No. Q9Y4P1
Gene Alias 2510009N07Rik; APG4 (ATG4) autophagy-related homolog B; APG4 autophagy 4 homolog B; APG4B; ATG4 autophagy related 4 homolog B; Atg4b; atg4b protein; Atg4bl; AUT2B; Aut2B1; Aut2b2; AUTL1; AUT-like 1 cysteine; AUT-like 1 cysteine endopeptidase; AUT-like 1, cysteine endopeptidase; autophagin 1; autophagin-1; Autophagin-2B; autophagy related 4 homolog B; autophagy related 4B cysteine peptidase; autophagy related 4B, cysteine peptidase; autophagy-related 4B; autophagy-related cysteine endopeptidase 1; Autophagy-related cysteine endopeptidase 2B; autophagy-related protein 4 homolog B; AW048066; bAut2B; Cysteine protease ATG4B; cysteine protease involved in autophagy APG4-B; hAPG4B; KIAA0943
Gene Symbols Atg4b
Host Species Rabbit
Immunogen A synthetic peptide (CLERFFDSEDED) corresponding to the C-terminus of human ATG4B protein (aa 377-387).
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23192, 316640
Target Species Human, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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