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Invitrogen™ ATG4B Recombinant Rabbit Monoclonal Antibody (JE59-97)
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Catalog No. FEMA550822
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FEMA550822 100 μL
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Catalog No. FEMA550822 Supplier Invitrogen™ Supplier No. MA550822
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Description

Rabbit Recombinant Monoclonal Antibody

Positive control: 293T cell lysate, Jurkat cell lysate, PC-12 cell lysate, mouse heart tissue lysate, mouse pancreas tissue lysate. Predicted band size: 44 kDa Subcellular Location: Cytoplasm, cytosol, Cytoplasmic vesicle, autophagosome, Endoplasmic reticulum, Mitochondrion.

Cysteine protease ATG4b is an enzyme which is coded by ATG4b gene. Autophagy is a critical cellular homeostatic process that controls the turnover of damaged organelles and protein. ATG4bis a deubiquitin-like protease that plays dual roles in the core machinery of autophagy. ATG4b, cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3, GABARAPL1, GABARAPL2 and GABARAP, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. ATG4b is mainly expressed in the skeletal muscle, brain, heart, liver and pancreas.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ATG4B
Applications Western Blot
Classification Recombinant Monoclonal
Clone JE59-97
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation TBS with 0.05% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
Gene Atg4b
Gene Accession No. Q8BGE6, Q9Y4P1
Gene Alias 2510009N07Rik; APG4 (ATG4) autophagy-related homolog B; APG4 autophagy 4 homolog B; APG4B; ATG4 autophagy related 4 homolog B; Atg4b; atg4b protein; Atg4bl; AUT2B; Aut2B1; Aut2b2; AUTL1; AUT-like 1 cysteine; AUT-like 1 cysteine endopeptidase; AUT-like 1, cysteine endopeptidase; autophagin 1; autophagin-1; Autophagin-2B; autophagy related 4 homolog B; autophagy related 4B cysteine peptidase; autophagy related 4B, cysteine peptidase; autophagy-related 4B; autophagy-related cysteine endopeptidase 1; Autophagy-related cysteine endopeptidase 2B; autophagy-related protein 4 homolog B; AW048066; bAut2B; Cysteine protease ATG4B; cysteine protease involved in autophagy APG4-B; hAPG4B; KIAA0943
Gene Symbols Atg4b
Host Species Rabbit
Immunogen Recombinant protein within Human ATG4B aa 221-320/393.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23192, 316640, 66615
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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