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Invitrogen™ ATG4C Polyclonal Antibody
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Catalog No. PIPA5102357
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PIPA5102357 100 μL
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Catalog No. PIPA5102357 Supplier Invitrogen™ Supplier No. PA5102357
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total ATG4C.

ATG4C is involved in autophagy, the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding the same protein, have been characterized. Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes. Highly expressed in skeletal muscle, heart, liver and testis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ATG4C
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene ATG4C
Gene Accession No. Q811C2, Q96DT6
Gene Alias APG4 (ATG4) autophagy-related homolog C; APG4 autophagy 4 homolog C; APG4C; APG4-C; ATG4 autophagy related 4 homolog C; ATG4C; Atg4cl; AUTL1; AUTL3; AUT-like 1, cysteine endopeptidase; AUT-like 3 cysteine endopeptidase; autophagin 3; autophagin-3; autophagy related 4C cysteine peptidase; autophagy related 4C, cysteine peptidase; autophagy-related 4C; autophagy-related cysteine endopeptidase 3; Autophagy-related protein 4 homolog C; cysteine peptidase; cysteine protease ATG4C; cysteine protease involved in autophagy; FLJ14867
Gene Symbols ATG4C
Host Species Rabbit
Immunogen A synthesized peptide derived from human ATG4C(Accession Q96DT6), corresponding to amino acid residues L29-F79.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 242557, 313391, 84938
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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