Invitrogen™ ATG4C Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA572814

Catalog No. PIPA572814

Description

ATG4C Polyclonal Antibody for Western Blot, IHC (P), ELISA

ATG4C is involved in autophagy, the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding the same protein, have been characterized. Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes. Highly expressed in skeletal muscle, heart, liver and testis.

Specifications

• Antigen: ATG4C
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ATG4C
• Gene Alias: APG4 (ATG4) autophagy-related homolog C; APG4 autophagy 4 homolog C; APG4C; APG4-C; ATG4 autophagy related 4 homolog C; ATG4C; Atg4cl; AUTL1; AUTL3; AUT-like 1, cysteine endopeptidase; AUT-like 3 cysteine endopeptidase; autophagin 3; autophagin-3; autophagy related 4C cysteine peptidase; autophagy related 4C, cysteine peptidase; autophagy-related 4C; autophagy-related cysteine endopeptidase 3; Autophagy-related protein 4 homolog C; cysteine peptidase; cysteine protease ATG4C; cysteine protease involved in autophagy; FLJ14867
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 242557, 313391, 84938
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: Q811C2, Q96DT6
• Gene Symbols: ATG4C
• Immunogen: ATG4C antibody for an 18 amino acid peptide near the carboxy terminus of human ATG4C. The immunogen is within the last 50 amino acids of ATG4C.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG