Invitrogen™ ATG4D Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA528363

Catalog No. PIPA528363

Description

Predicted reactivity: Mouse (95%), Rat (95%), Pig (97%), Bovine (98%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Atg4D (autophagy-related gene 4D), also known as APG4D or AUTL4, is a 474 amino acid protein that localizes to the cytoplasm and belongs to the C-54 family of cysteine proteases. Expressed predominately in skeletal muscle, but also present in testis, Atg4D functions as a cysteine protease that is required for autophagy and functions to specifically cleave the C-terminal region of target proteins, thereby allowing the target proteins to bind to autophagosomes. The enzymatic activity of Atg4D is inhibited by Nethylmaleimide, a thiol reactive compound that is capable of modifying cystine residues in proteins and peptides.

Specifications

• Antigen: ATG4D
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Atg4d
• Gene Alias: 9830134P12Rik; APG4 (ATG4) autophagy-related homolog D; APG4 autophagy 4 homolog D; APG4D; APG4-D; ATG4 autophagy related 4 homolog D; Atg4d; Atg4dl; Autl4; AUT-like 4 cysteine endopeptidase; AUT-like 4, cysteine endopeptidase; Autophagin-4; autophagy related 4D cysteine peptidase; autophagy related 4D, cysteine peptidase; autophagy-related 4D; autophagy-related cysteine endopeptidase 4; Autophagy-related protein 4 homolog D; cysteine protease ATG4D; Cysteine protease ATG4D, mitochondrial; cysteine protease involved in autophagy; cysteine protease involved in autophagy APG4-D
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 235040, 686505, 84971
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1.1 mg/mL
• Formulation: PBS with 20% glycerol and 0.025% ProClin 300; pH 7
• Gene Accession No.: Q86TL0, Q8BGV9
• Gene Symbols: Atg4d
• Immunogen: Recombinant fragment corresponding to a region within amino acids 220 and 441 of Human ATG4D.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG