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Invitrogen™ ATGL Monoclonal Antibody (K.751.7)

Rabbit Monoclonal Antibody

Supplier:  Invitrogen™ MA514990

Catalog No. PIMA514990


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Description

Description

It is not recommended to aliquot this antibody.

Lipolytic enzymes are required for mobilization of fatty acids from triglyceride stores in adipose tissue. Energy homeostasis is affected by dysfunctional lipolysis and may contribute to the pathogenesis of obesity and insulin resistance. Until recently, hormone-sensitive lipase (HSL) was the only enzyme known to hydrolyze triglycerides in mammalian adipose tissue. It is now thought that a second enzyme, adipose triglyceride lipase (ATGL), catalyzes the initial step in triglyceride hydrolysis. ATGL is highly expressed in adipose tissue of mice and humans. It exhibits high substrate specificity for triacylglycerol and is associated with lipid droplets. Inhibition of ATGL markedly decreases total adipose acyl-hydrolase activity. Thus, ATGL and HSL coordinately catabolize stored triglycerides in adipose tissue of mammals.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

ATGL
Monoclonal
23 μg/mL
0.01M HEPES with 100 μg/mL BSA, 50% glycerol, 0.15M NaCl and <0.02% sodium azide; pH 7.5
P0C548, Q8BJ56
PNPLA2
Synthetic peptide corresponding to residues surrounding Pro469 of mouse ATGL.
100 μL
Primary
Mouse, Rat
Antibody
IgG
Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
K.751.7
Unconjugated
PNPLA2
0610039C21Rik; 1110001C14Rik; adipose triglyceride lipase; ATGL; ATGL DESNUTRIN; calcium-independent phospholipase A2; Desnutrin; DKFZp667M109; FP17548; IPLA2 zeta; iPLA2zeta; IPLA2-zeta; mutant patatin-like phospholipase domain containing 2; patatin like phospholipase domain containing 2; patatin-like phospholipase domain containing 2; patatin-like phospholipase domain containing protein 2; patatin-like phospholipase domain-containing protein 2; PEDF R; PEDF-R; pigment epithelium-derived factor; plpl; plpl2; Pnpla2; RGD1309044; transport-secretion protein; Transport-secretion protein 2; transport-secretion protein 2.2; triglyceride hydrolase; TTS 2.2; TTS2; TTS2.2; TTS-2.2
Rabbit
Affinity chromatography
RUO
361676, 66853
-20°C
Liquid
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