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Invitrogen™ ATGL Recombinant Rabbit Monoclonal Antibody (10Y4M10)
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Catalog No. PIMA538135
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PIMA538135 100 μL
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Catalog No. PIMA538135 Supplier Invitrogen™ Supplier No. MA538135
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Description

Rabbit Recombinant Monoclonal Antibody

Positive Samples: HeLa, A-431, U-87MG, Mouse brain, Mouse kidney, Mouse heart muscle, Rat brain, Rat kidney, Rat heart muscle Immunogen sequence: LPARLNEALL EACVEPTDLL TTLSNMLPVR LATAMMVPYT LPLESALSFT IRLLEWLPDV PEDIRWMKEQ TGSICQYLVM RAKRKLGRHL PSRLP.

Lipolytic enzymes are required for mobilization of fatty acids from triglyceride stores in adipose tissue. Energy homeostasis is affected by dysfunctional lipolysis and may contribute to the pathogenesis of obesity and insulin resistance. Until recently, hormone-sensitive lipase (HSL) was the only enzyme known to hydrolyze triglycerides in mammalian adipose tissue. It is now thought that a second enzyme, adipose triglyceride lipase (ATGL), catalyzes the initial step in triglyceride hydrolysis. ATGL is highly expressed in adipose tissue of mice and humans. It exhibits high substrate specificity for triacylglycerol and is associated with lipid droplets. Inhibition of ATGL markedly decreases total adipose acyl-hydrolase activity. Thus, ATGL and HSL coordinately catabolize stored triglycerides in adipose tissue of mammals.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ATGL
Applications ELISA, Western Blot
Classification Recombinant Monoclonal
Clone 10Y4M10
Concentration 0.8 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene PNPLA2
Gene Accession No. P0C548, Q8BJ56, Q96AD5
Gene Alias 0610039C21Rik; 1110001C14Rik; adipose triglyceride lipase; ATGL; ATGL DESNUTRIN; calcium-independent phospholipase A2; Desnutrin; DKFZp667M109; FP17548; IPLA2 zeta; iPLA2zeta; IPLA2-zeta; mutant patatin-like phospholipase domain containing 2; patatin like phospholipase domain containing 2; patatin-like phospholipase domain containing 2; patatin-like phospholipase domain containing protein 2; patatin-like phospholipase domain-containing protein 2; PEDF R; PEDF-R; pigment epithelium-derived factor; plpl; plpl2; Pnpla2; RGD1309044; transport-secretion protein; Transport-secretion protein 2; transport-secretion protein 2.2; triglyceride hydrolase; TTS 2.2; TTS2; TTS2.2; TTS-2.2
Gene Symbols PNPLA2
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 300-394 of human ATGL / PNPLA2 (NP_0651091).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 361676, 57104, 66853
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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