Invitrogen™ ATGL Recombinant Rabbit Monoclonal Antibody (10Y4M10)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA538135

Catalog No. PIMA538135

Description

Positive Samples: HeLa, A-431, U-87MG, Mouse brain, Mouse kidney, Mouse heart muscle, Rat brain, Rat kidney, Rat heart muscle Immunogen sequence: LPARLNEALL EACVEPTDLL TTLSNMLPVR LATAMMVPYT LPLESALSFT IRLLEWLPDV PEDIRWMKEQ TGSICQYLVM RAKRKLGRHL PSRLP.

Lipolytic enzymes are required for mobilization of fatty acids from triglyceride stores in adipose tissue. Energy homeostasis is affected by dysfunctional lipolysis and may contribute to the pathogenesis of obesity and insulin resistance. Until recently, hormone-sensitive lipase (HSL) was the only enzyme known to hydrolyze triglycerides in mammalian adipose tissue. It is now thought that a second enzyme, adipose triglyceride lipase (ATGL), catalyzes the initial step in triglyceride hydrolysis. ATGL is highly expressed in adipose tissue of mice and humans. It exhibits high substrate specificity for triacylglycerol and is associated with lipid droplets. Inhibition of ATGL markedly decreases total adipose acyl-hydrolase activity. Thus, ATGL and HSL coordinately catabolize stored triglycerides in adipose tissue of mammals.

Specifications

• Antigen: ATGL
• Classification: Recombinant Monoclonal
• Concentration: 0.8 mg/mL
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P0C548, Q8BJ56, Q96AD5
• Gene Symbols: PNPLA2
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 300-394 of human ATGL / PNPLA2 (NP_0651091).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: ELISA, Western Blot
• Clone: 10Y4M10
• Conjugate: Unconjugated
• Gene: PNPLA2
• Gene Alias: 0610039C21Rik; 1110001C14Rik; adipose triglyceride lipase; ATGL; ATGL DESNUTRIN; calcium-independent phospholipase A2; Desnutrin; DKFZp667M109; FP17548; IPLA2 zeta; iPLA2zeta; IPLA2-zeta; mutant patatin-like phospholipase domain containing 2; patatin like phospholipase domain containing 2; patatin-like phospholipase domain containing 2; patatin-like phospholipase domain containing protein 2; patatin-like phospholipase domain-containing protein 2; PEDF R; PEDF-R; pigment epithelium-derived factor; plpl; plpl2; Pnpla2; RGD1309044; transport-secretion protein; Transport-secretion protein 2; transport-secretion protein 2.2; triglyceride hydrolase; TTS 2.2; TTS2; TTS2.2; TTS-2.2
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 361676, 57104, 66853
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid