ATM Polyclonal Antibody, Bethyl Laboratories

Goat Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-155-6969	Bethyl Laboratories, Inc A300136AT	20 μL

Description

The recommended shelf life for this product is 1 year from date of receipt.

Ataxia-telangiectasia Mutated (ATM) is a protein that belongs to the PI3/PI4 kinase family. Ataxia-telangiectasia is a rare autosomal recessive disorder characterized by progressive neurologic degeneration, immunologic deficiency, and an increased risk of lymphoid cancer. The ATM gene codes for a protein belonging to the phosphoinositide 3-kinase (PI3K) superfamily. ATM phosphorylates proteins instead of lipid and has many downstream targets that act as cell-cycle regulators including: P53, Mdm2, BRCA1, and SMC1. The ATM protein is responsible for repairing double-stranded DNA breaks that occur because of ionizing radiation and other mutagens. The ATM's C-terminal region has extensive homology to the catalytic domains of phosphatidylinositol 3-kinases (PI3 kinases). Studies have shown that ATM becomes autophosphorylated and upregulated by exposure to ionizing radiation. AT cells are hypersensitive to ionizing radiation, impaired in mediating the inhibition of DNA synthesis and display delays in p53 induction. Further, DNA damage caused by ionizing irradiation activates ATM-kinase, leading to a cascade of kinase reactions that regulate cell cycle, apoptosis, and DNA damage repair. Studies have linked ATM to apoptosis along with Nbs1 and Chk2 in the E2F1 pathway.

Specifications

• Antigen: ATM
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: TBS with 0.1% BSA and 0.09% sodium azide
• Gene Alias: Serine-protein kinase ATM, EC 2.7.1.37, Ataxia telangiectasia mutated
• Immunogen: Between 2550 and 2600
• Primary or Secondary: Primary
• Content And Storage: 4° C
• Gene: ATM

• Applications: Western Blot
• Conjugate: Unconjugated
• Host Species: Goat
• Target Species: Human, Mouse
• Gene Accession No.: Q13315, Q62388
• Gene ID (Entrez): 11920, 472
• Isotype: IgG
• Purification Method: Antigen affinity chromatography
• Product Type: Antibody