Invitrogen™ ATOH1 Polyclonal Antibody

Catalog No.	Quantity
FEPA5144928	100 μL

Catalog No. FEPA5144928 Supplier Invitrogen™ Supplier No. PA5144928

Description

Rabbit Polyclonal Antibody

Immunogen sequence: WLAPTLQGIC TARAAQYLLH SPELGASEAA APRDEVDGRG ELVRRSSGGA SSSKSPGPVK VREQLCKLKG GVVVDELGCS RQRAPSSKQV NGV Antigen sequence identity: Mouse 89%; Rat 89%.

The Drosophila atonal gene produces a protein with basic helix loop helix (bHLH) domains that plays an essential role in the development of the Drosophila nervous system. Mammalian atonal homolog 1 (MATH-1) is a helix-loop-helix (HLH) transcription factor that is structurally homologous to the product of the Drosophila proneural gene atonal. MATH-1, so known as Atoh1, Ath1 or HATH-1, is a 351 amino acid protein with an atonal-related basic HLH domain. In mice, expression of MATH-1 takes place by embryonic day 9. 5 and initially localizes to the cranial ganglions and the dorsal part of the central nervous system. Prominent expression of MATH-1 is in the dorsal part of the central nervous system but becomes restricted to the external granular layer of the cerebellum by day 18 and is undetectable in the adult nervous system. It is suggested that MATH-1 may play a role in the differentiation of subsets of neural cells by activating E box-dependent transcription.

Specifications

• Antigen: ATOH1
• Applications: Immunocytochemistry
• Classification: Polyclonal
• Concentration: 0.4 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene: Atoh1
• Gene Accession No.: Q92858
• Gene Alias: ATH1; Atoh1; atonal bHLH transcription factor 1; atonal homolog 1; atonal homolog 1 (Drosophila); atonal homolog bHLH transcription factor 1; BHLHA14; Class A basic helix-loop-helix protein 14; H MATH-1; Hath1; Helix-loop-helix protein hATH-1; helix-loop-helix protein mATH-1; Math1; MATH-1; Protein atonal homolog 1; RGD1565171
• Gene Symbols: Atoh1
• Host Species: Rabbit
• Immunogen: Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence. Antigen range: 64-156. Recombinant protein control fragment (Product #RP-110140).
• Purification Method: Affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 474
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Format: Liquid
• Isotype: IgG