Invitrogen™ ATOH8 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA565024

Catalog No. PIPA565024

Description

Immunogen sequence: MKHIPVLEDGP WKTVCVKELN GLKKLKRKGK EPARRANGYK TFRLDLEAPE PRAVATNGLR DRTHRLQPVP VPVPVPVPYG APHR Highest antigen sequence identity to the following orthologs - mouse 73%, rat 72%.

Basic helix-loop-helix (bHLH) transcription factors play important roles in differentiation processes during embryonic development of vertebrates. ATOH8 (MATH6) is a tissue-restricted member of the atonal superfamily of bHLH transcription factors that exhibits 43-57% identity in the bHLH domain with other mammalian atonal paralogs including the NeuroD and Neurogenin factors. In the mouse, ATOH8 has been implicated in the specification and differentiation of neuronal cell lineages in the brain and may also participate in kidney development. Recent studies show that ATOH8 is a novel component of the pancreatic transcriptional network during embryonic development and suggest a potential role as a modulator of the differentiation program initiated by the pro-endocrine factor Neurog3. It is indispensable for early embryonic development, suggesting a more widespread function for this factor in tissue-specific differentiation processes that are dependent on class II bHLH genes.

Specifications

• Antigen: ATOH8
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ATOH8
• Gene Alias: 4933425C05Rik; Ath6; Atoh8; atonal bHLH transcription factor 8; atonal homolog 6; atonal homolog 8; atonal homolog 8 (Drosophila); atonal homolog bHLH transcription factor 8; basic helix loop helix transcription factor 6; basic helix-loop-helix transcription factor 6; bHLHa21; Class A basic helix-loop-helix protein 21; hATH6; Helix-loop-helix protein hATH-6; helix-loop-helix protein mATH-6; mATH6; Okadin; Protein atonal homolog 8; RGD1561512
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 84913
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q96SQ7
• Gene Symbols: ATOH8
• Immunogen: Recombinant Human ATOH8. Recombinant protein control fragment (Product #RP-105790).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov