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Invitrogen™ ATP11A Polyclonal Antibody
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Catalog No. PIPA557324
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100 μL
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PIPA557324 100 μL
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Catalog No. PIPA557324 Supplier Invitrogen™ Supplier No. PA557324
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: TCYACKLFRR NTQLLELTTK RIEEQSLHDV LFELSKTVLR HSGSLTRDNL SGLSADMQDY GLIIDGAALS LIMKPREDGS SGNYRELFLE ICRSC Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 90%.

ATP11A is a widely expressed integral membrane ATPase. ATP11A is probably phosphorylated in its intermediate state and likely drives the transport of ions such as calcium or other molecules across membranes. While the exact molecule ATP11A transports is unknown, increased expression of ATP11A mRNA has been observed in murine leukemia cells made resistant to anti-cancer drugs such as farnesyltransferase inhibitors (FTIs). Furthermore, overexpression of ATP11A provided protection against the FTI SCH66336 while knockdown of ATP11A via siRNA made cells more sensitive to this drug. Other reports suggest that elevated levels of ATP11A mRNA may also be a predictive marker of metastasis in colorectal cancer patients.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ATP11A
Applications Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene ATP11A
Gene Accession No. P98196
Gene Alias 4930558F19Rik; ATP11A; ATPase 11A, class VI; ATPase 11A, p type; ATPase class VI type 11A; ATPase IS; ATPase phospholipid transporting 11A; ATPase, class 1, member h; ATPase, class VI, type 11A; Atpc1h; ATPIH; ATPIS; AU040868; Ih; KIAA1021; P4-ATPase flippase complex alpha subunit ATP11A; phospholipid-translocating ATPase; potential phospholipid-transporting ATPase IH; probable phospholipid-transporting ATPase IH; RP11-120K24.1; Ua20
Gene Symbols ATP11A
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human ATP11A. Recombinant protein control fragment (Product #RP-94972).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23250
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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