Invitrogen™ ATP11C Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5109426

Catalog No. PIPA5109426

Description

Immunogen sequence: DGHKYKGVTQ EVDGLSQTDG TLTYFDKVDK NREELFLRAL CLCHTVEIKT NDAVDGATES AELTYISSSP DEIALVKGAK RYGFTFLGNR NGYMRVENQR KEIEEYELLH TLNFDAVRRR MSVIVKTQEG DILLFCKGAD SAVFPRVQNH EIELTKVHVE RNAMDGYRTL CVAFKEIAPD DYERINRQLI EAKMALQDRE EKMEKVFDDI ETNMNLIGAT A.

The ATP11C gene encodes a protein that belongs to the P4-ATPase family, specifically functioning as a phospholipid-transporting ATPase. ATP11C plays a critical role in the maintenance of phospholipid asymmetry across the cell membrane by transporting aminophospholipids from the outer leaflet to the inner leaflet of the plasma membrane. This activity is essential for various biological processes, including cell membrane integrity, cell signaling, and apoptosis. ATP11C is particularly important in hematopoiesis, influencing the development of B cells and red blood cells. Mutations or dysregulation in ATP11C can lead to disruptions in cell membrane dynamics and are associated with immunological disorders and anemia. Research on ATP11C continues to focus on its role in phospholipid transport and its implications for cellular function and disease, particularly in the context of blood-related disorders.

Specifications

• Antigen: ATP11C
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Atp11c
• Gene Alias: A330005H02Rik; AI315324; Atp11c; Atpase 11c, p type; ATPase class VI type 11C; ATPase IQ; ATPase phospholipid transporting 11C; ATPase, class VI, type 11C; ATPIG; ATPIQ; I79_007666; Ig; P4-ATPase flippase complex alpha subunit ATP11C; phospholipid-transporting ATPase 11C; Phospholipid-transporting ATPase IG; probable phospholipid-transporting ATPase 11C; probable phospholipid-transporting ATPase IG; putative phospholipid-transporting ATPase 11C
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 286410, 320940
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 2.22 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: Q8NB49, Q9QZW0
• Gene Symbols: Atp11c
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 430-650 of human ATP11C (NP_775965.2).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov