Invitrogen™ ATP1B1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA529719

Catalog No. PIPA529719

Description

Recommended positive controls: K562, HL-60, mouse brain, Rat brain. Predicted reactivity: Mouse (90%), Rat (92%), Dog (91%), Pig (89%), Rabbit (87%), Sheep (91%), Rhesus Monkey (96%), Chimpanzee (99%), Guinea pig (86%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been described, but their biological validity is not known.

Specifications

• Antigen: ATP1B1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ATP1B1
• Gene Alias: adenosinetriphosphatase; ATP1B; ATP1B1; Atp4b; ATPase beta subunit; ATPase Na+/K+ transporting subunit beta 1; ATPase, Na+/K+ transporting, beta 1 polypeptide; Atpb; Atpb-1; ATPBS; Beta 1-subunit of Na(+),K(+)-ATPase; hypothetical protein LOC519758; MGC1798; Na, K-ATPase beta-1 polypeptide; Na,K-ATPase beta 1 subunit; Na+, K+-ATPase; Na+, K+-ATPase beta-subunit; Na+,K+-ATPase beta 1 subunit; Na+/K+ ATPase Beta; NKbeta1; OTTHUMP00000032537; OTTHUMP00000032538; P-type ATPase; Sodium Potassium ATPase; sodium pump subunit beta-1; sodium/potassium ATPase beta subunit; sodium/potassium-dependent ATPase beta-1 subunit; sodium/potassium-dependent ATPase subunit beta-1; sodium/potassium-transporting ATPase beta-1 chain; sodium/potassium-transporting ATPase subunit beta-1; sodium-potassium ATPase subunit beta 1 (non-catalytic); unnamed protein product
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 11931, 25650, 481
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: P05026, P07340, P14094
• Gene Symbols: ATP1B1
• Immunogen: Recombinant protein encompassing a sequence within the Extracellular domain of human Sodium Potassium ATPase Beta 1. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov