ATP1B1 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA588526

Catalog No. PIPA588526

Description

Immunogen sequence: KPTYQDRVAP PGLTQIPQIQ KTEISFRPND PKSYEAYVLN IVRFLEKYKD SAQRDDMIFE DCGDVPSEPK ERGDFNHERG ERKVCRFKLE WLGNCSGLND ETYGYKEGKP CIIIKLNRVL GFKPKPPKNE SLETYPVMKY NPNVLPVQCT GKRDEDKDKV GNVEYFGLGN SPGFPL; Positive Samples: U-251MG, Mouse brain, Mouse liver, Mouse kidney, Rat kidney, Rat brain; Cellular Location: Cell membrane, Single-pass type II membrane protein

The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been described, but their biological validity is not known.

Specifications

• Antigen: ATP1B1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ATP1B1
• Gene Alias: adenosinetriphosphatase, ATP1B, ATP1B1, Atp4b, ATPase beta subunit, ATPase Na+/K+ transporting subunit beta 1, ATPase, Na+/K+ transporting, beta 1 polypeptide, Atpb, Atpb-1, ATPBS, Beta 1-subunit of Na(+),K(+)-ATPase, hypothetical protein LOC519758, MGC1798, Na, K-ATPase beta-1 polypeptide, Na,K-ATPase beta 1 subunit, Na+, K+-ATPase, Na+, K+-ATPase beta-subunit, Na+,K+-ATPase beta 1 subunit, Na+/K+ ATPase Beta, NKbeta1, OTTHUMP00000032537, OTTHUMP00000032538, P-type ATPase, Sodium Potassium ATPase, sodium pump subunit beta-1, sodium/potassium ATPase beta subunit, sodium/potassium-dependent ATPase beta-1 subunit, sodium/potassium-dependent ATPase subunit beta-1, sodium/potassium-transporting ATPase beta-1 chain, sodium/potassium-transporting ATPase subunit beta-1, sodium-potassium ATPase subunit beta 1 (non-catalytic), unnamed protein product
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 11931, 25650, 481
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunocytochemistry, Western Blot
• Concentration: 2.59 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
• Gene Accession No.: P05026, P07340, P14094
• Gene Symbols: ATP1B1
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 65-240 of human ATP1B1 (NP_0016681)
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG