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Invitrogen™ ATP2C2 Polyclonal Antibody
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Catalog No. PIPA562577
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100 μL
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PIPA562577 100 μL
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Catalog No. PIPA562577 Supplier Invitrogen™ Supplier No. PA562577
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: LEKDEEEALI DEQSELKAIE KEKKVTALPP KEACKCQKED LARAFCVDLH TGLSEFSVTQ RRLAHGWNEF VADNSEPVWK KYLDQ Highest antigen sequence identity to the following orthologs: Mouse - 78%, Rat - 76%.

ATP2C2, also known as secretory pathway Ca2+/Mn2+-ATPase (SPCA) 2, belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium from the cytosol to the Golgi lumen. Defects in the related gene ATP2C1 cause Hailey-Hailey disease, for which ATP2C2 does not compensate, suggesting that ATP2C2 plays other physiological roles. Unlike ATP2C1, ATP2C2 has a much more restricted expression pattern and displays a higher maximal turnover rate for overall Ca2+-ATPase reaction and a lower apparent affinity for cytosolic Ca2+ activation of phosphorylation. Overexpression of ATP2C2 in mammary tumors result a Ca2+ influx via the store-operated Ca2+ channel ORAI1 and independent of the STIM1 and STIM2 sensors.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ATP2C2
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.6 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene ATP2C2
Gene Accession No. O75185
Gene Alias 1810010G06Rik; Atp2c2; ATPase 2C2; ATPase secretory pathway Ca2+ transporting 2; ATPase, Ca++ transporting, type 2C, member 2; calcium-transporting ATPase type 2C member 2; Kiaa0703; mKIAA0703; Secretory pathway Ca(2+)-ATPase 2; secretory pathway Ca2+-ATPase; secretory pathway calcium ATPase 2; Spca2
Gene Symbols ATP2C2
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human ATP2C2. Recombinant protein control fragment (Product #RP-95779).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 9914
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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