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Invitrogen™ ATP2C2 Polyclonal Antibody
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Catalog No. PIPA5103685
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Quantity:
100 μL
Catalog No. Quantity
PIPA5103685 100 μL
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Catalog No. PIPA5103685

Supplier: Invitrogen™ PA5103685

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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total ATP2C2.

ATP2C2, also known as secretory pathway Ca2+/Mn2+-ATPase (SPCA) 2, belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium from the cytosol to the Golgi lumen. Defects in the related gene ATP2C1 cause Hailey-Hailey disease, for which ATP2C2 does not compensate, suggesting that ATP2C2 plays other physiological roles. Unlike ATP2C1, ATP2C2 has a much more restricted expression pattern and displays a higher maximal turnover rate for overall Ca2+-ATPase reaction and a lower apparent affinity for cytosolic Ca2+ activation of phosphorylation. Overexpression of ATP2C2 in mammary tumors result a Ca2+ influx via the store-operated Ca2+ channel ORAI1 and independent of the STIM1 and STIM2 sensors.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ATP2C2
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene ATP2C2
Gene Accession No. O75185
Gene Alias 1810010G06Rik; Atp2c2; ATPase 2C2; ATPase secretory pathway Ca2+ transporting 2; ATPase, Ca++ transporting, type 2C, member 2; calcium-transporting ATPase type 2C member 2; Kiaa0703; mKIAA0703; Secretory pathway Ca(2+)-ATPase 2; secretory pathway Ca2+-ATPase; secretory pathway calcium ATPase 2; Spca2
Gene Symbols ATP2C2
Host Species Rabbit
Immunogen A synthesized peptide derived from human ATP2C2(Accession O75185), corresponding to amino acid residues D505-L555.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 9914
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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