Invitrogen™ ATP4A Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5143987

Catalog No. PIPA5143987

Description

Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL. Positive Control - WB: rat testis tissue, rat stomach tissue, mouse testis tissue, mouse stomach tissue. IHC: rat stomach tissue. Flow: Daudi cell. Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

The ATP4A gene encodes the alpha subunit of the gastric H+/K+ ATPase, an enzyme crucial for gastric acid secretion in the stomach. This proton pump resides in the parietal cells of the gastric mucosa and is responsible for exchanging potassium ions (K+) for hydrogen ions (H+), effectively acidifying the stomach contents. ATP4A plays a significant role in maintaining the acidic environment necessary for digestion and defense against pathogens. The ATPase's activity is tightly regulated by various factors, including hormones like gastrin and histamine, to ensure optimal stomach function. Mutations in ATP4A can lead to disorders related to gastric acidity, such as hypochlorhydria (low stomach acid), which can impact digestion and absorption of nutrients. Understanding ATP4A's function and its regulatory mechanisms is essential for developing treatments for conditions like peptic ulcer disease and gastroesophageal reflux disease, where gastric acid secretion is disrupted.

Specifications

• Antigen: ATP4A
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ATP4A
• Gene Alias: ATP4A; ATP6A; ATPase H+/K+ transporting alpha subunit; ATPase, H+/K+ exchanging, alpha polypeptide; ATPase, H+/K+ transporting, alpha polypeptide; gastric H(+)/K(+) ATPase subunit alpha; gastric H,K-ATPase alpha subunit; gastric H,K-ATPase catalytic subunit; gastric H+/K+ ATPase alpha subunit; gastric hydrogen-potassium ATPase; H(+)-K(+)-ATPase alpha subunit; potassium-transporting ATPase alpha chain 1; Proton pump
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 11944, 24216, 495
• Content And Storage: -20°C
• Form: Lyophilized

• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 500 μg/mL
• Formulation: PBS with 4mg trehalose and no preservative
• Gene Accession No.: P09626, P20648, Q64436
• Gene Symbols: ATP4A
• Immunogen: A synthetic peptide corresponding to a sequence of human ATP4A (AELEQKYQTSATKGLSASLAAELLLRD).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG