Invitrogen™ ATP6AP1 Recombinant Rabbit Monoclonal Antibody (4Z7Q3)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA551486

Catalog No. FEMA551486

Description

Immunogen sequence: MMAAMATARV RMGPRCAQAL WRMPWLPVFL SLAAAAAAAA AEQQVPLVLW SSDRDLWAPA ADTHEGHITS DLQLSTYLDP ALELGPRNVL LFLQDKLSIE.

Vacuolar-type H+-ATPase (V-ATPase) is a multisubunit enzyme responsible for acidification of eukaryotic intracellular organelles. V-ATPases pump protons against an electrochemical gradient, thereby synthesizing ATP. A peripheral V1 domain, which is responsible for ATP hydrolysis, and an integral V0 domain, which is responsible for proton translocation, compose the V-ATPase. Nine subunits (A-H) make up the V1 domain and five subunits (a, d, c, c' and c) make up the V0 domain. ATP6AP1 (ATPase, H+ transporting, lysosomal accessory protein 1), also known as 16A, CF2, Ac45, XAP3, ATP6S1, VATPS1 (vacuolar ATP synthase S1 accessory protein) or ATP6IP1, is a type I transmembrane, V-ATPase accessory protein that is predominantly expressed in endocrine and neuronal cells. ATP6AP1 is responsible for targeting the V-ATPase enzyme to specialized complex vacuolar systems. Via its cytoplasmic tail, ATP6AP1 interacts with subunits of the V0 domain. The disruption of this interaction in osteoclasts results in impaired bone resorption, suggesting an important role for ATP6AP1 in proper osteoclastic bone resorption.

Specifications

• Antigen: ATP6AP1
• Classification: Recombinant Monoclonal
• Concentration: 0.2 mg/mL
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.05% ProClin 300; pH 7.3
• Gene Accession No.: Q15904, Q9R1Q9
• Gene Symbols: ATP6AP1
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human ATP6AP1 (NP_001174.2).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Format: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Clone: 4Z7Q3
• Conjugate: Unconjugated
• Gene: ATP6AP1
• Gene Alias: 16A; Ac45; AI316502; Atp6ap1; ATP6IP1; Atp6s1; ATPase H+ transporting accessory protein 1; ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1; ATPase, H+ transporting, lysosomal accessory protein 1; ATPase, H+ transporting, lysosomal interacting protein 1; AW108110; C7-1; C7-1 protein; CF2; H-ATPase subunit; mFLJ00383; MGC129781; protein C7-1; Protein XAP-3; vacuolar H+ ATPase accessory subunit 1; vacuolar proton pump subunit S1; V-ATPase Ac45 subunit; V-ATPase S1 accessory protein; V-ATPase subunit Ac45; V-ATPase subunit S1; VATPS1; V-type proton ATPase subunit S1; XAP3; XAP-3
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 537, 54411
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid
• Isotype: IgG