Invitrogen™ ATP6V0B Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA569355

Catalog No. PIPA569355

Description

This target displays homology in the following species: Cow: 100%; Dog: 93%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 100%.

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is part of the transmembrane V0 domain and is the human counterpart of yeast VMA16. Two alternatively spliced transcript variants that encode different proteins have been found for this gene.

Specifications

• Antigen: ATP6V0B
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ATP6V0B
• Gene Alias: 23 kDa subunit of V-ATPase; 2310024H13Rik; ATP6F; ATP6V0B; ATPase H+ transporting V0 subunit b; ATPase, H+ transporting, lysosomal (vacuolar proton pump); ATPase, H+ transporting, lysosomal 21kDa, V0 subunit B; ATPase, H+ transporting, lysosomal V0 subunit B; ATPase, H+ transporting, lysosomal, 21-KD, V0 subunit C-prime, prime; ATPase, H+ transporting, lysosomal, subunit F; ATPase, H+ transporting, V0 subunit B; H(+)-transporting two-sector ATPase, subunit F; HATPL; lysosomal 21kDa; Unknown (protein for MGC:134511); vacuol; vacuolar ATP synthase 21 kDa proteolipid subunit; vacuolar proton pump 21 kDa proteolipid subunit; V-ATPase 21 kDa proteolipid subunit; V-ATPase subunit c''; VMA16; V-type proton ATPase 21 kDa proteolipid subunit
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 298451
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 2% sucrose and 0.09% sodium azide
• Gene Accession No.: 0
• Gene Symbols: ATP6V0B
• Immunogen: synthetic peptide directed towards the N-terminal region of rat ATP6V0B.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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