ATP6V1B1 Monoclonal Antibody (OTI6D2), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA502519

Catalog No. 50-167-3572

Description

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c′, c′, and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of two V1 domain B subunit isoforms and is found in the kidney. Mutations in this gene cause distal renal tubular acidosis associated with sensorineural deafness.

Specifications

• Antigen: ATP6V1B1
• Classification: Monoclonal
• Concentration: 0.73 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: P15313
• Gene Symbols: ATP6V1B1
• Immunogen: Full length human recombit protein of human ATP6V1B1 produced in HEK293T cell.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Flow Cytometry, Immunocytochemistry, Immunofluorescence, Western Blot
• Clone: OTI6D2
• Conjugate: Unconjugated
• Gene: ATP6V1B1
• Gene Alias: ATP6B1, RTA1B, VATB, VMA2, VPP3
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 525
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid