Invitrogen™ ATP6V1B2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA552518

Catalog No. PIPA552518

Description

Immunogen sequence: MALRAMRGIV NGAAPELPVP TGGPAVGARE QALAVSRNYL SQPRLTYKTV SGVNGPLVIL DHVKFPRYAE IVHLTLPDGT KRSGQVLEVS GSKAVVQVFE Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 98%.

ATP6V1B2 encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of two V1 domain B subunit isoforms and is the only B isoform highly expressed in osteoclasts.

Specifications

• Antigen: ATP6V1B2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Atp6v1b2
• Gene Alias: AI194269; AI790362; ATP6B1B2; Atp6b2; Atp6v1b2; atp6v1bb; atp6v1bb protein; ATPase H+ transporting V1 subunit B2; ATPase, H transporting, lysosomal V1 subunit B2; ATPase, H+ transporting, lysosomal (vacuolar proton pump), beta 56/58 kDa, isoform 2; ATPase, H+ transporting, lysosomal 56/58kD, V1 subunit B, isoform 2; ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1; ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2; ATPase, H+ transporting, lysosomal V1 subunit B2; ATPase, H+ transporting, lysosomal, V1 subunit B, member b; ATPase, H+ transporting, lysosomal, V1 subunit B2; ATPase, H+ transporting, V1 subunit B, isoform 2; DOOD; endomembrane proton pump 58 kDa subunit; fj51e01; H+ transporting two-sector ATPase; H+-ATPase B subunit; H+-ATPase non-catalytic subunit B; HO57; lysosomal 56/58kDa; R74844; testicular secretory protein Li 65; vacuolar H+-ATPase; vacuolar H+-ATPase 56,000 subunit; vacuolar H+ATPase B2; vacuolar proton pump subunit B 2; vacuolar-type H+ transporting ATPase subunit B2; Vat2; VATB; vatB2; V-ATPase B2 subunit; V-ATPase subunit B 2; Vma2; VPP3; V-type proton ATPase subunit B, brain isoform; wu:fj51e01; zgc:109771; ZLS2
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 117596, 11966, 526
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.10 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P21281, P62814, P62815
• Gene Symbols: Atp6v1b2
• Immunogen: Recombinant protein corresponding to Human V-ATPase B2. Recombinant protein control fragment (Product #RP-89924).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG