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ATP7A Mouse anti-Human, Mouse, Rat, Clone: S60-4, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA527720

Catalog No. PIMA527720


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Description

Description

ATP7A (also known as Copper-transporting ATPase 1) functions as a transmembrane copper-translocating P-type ATPase and plays a vital role in systemic copper absorption in the gut and copper reabsorption in the kidney. Polarized epithelial cells such as Madin-Darby canine kidney cells are a physiologically relevant model for systemic copper absorption and reabsorption in vivo. Although ATP7A is not detectable in most normal tissues, it is expressed in a considerable fraction of many common tumor types. Increased expression of ATP7A renders cells resistant to cisplatin and carboplatin. Mutations in the ATP7A gene result in Menkes disease, which is fatal in early childhood.
Specifications

Specifications

ATP7A
Monoclonal
1 mg/ml
PBS with 50% glycerol and 0.09% sodium azide; pH 7.4
P70705, Q04656, Q64430
ATP7A, ATP 7A, ATPase Cu transporting, DSMAX, FLJ17790, MC1, MC 1, MK, MNK, OHS, Copper pump 1, Menke, OTTHUMP00000062077, SMAX3, ATPase copper transporting alpha polypeptide, ATPase Cu++ transporting alpha polypeptide (Menkes syndrome), Copper transporting ATPase 1, Cu++ transporting P type ATPase, Menkes disease associated protein, Menkes syndrome
Mouse
IgG2b
100 μg
-20°C
Primary
11977, 24941, 538
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (PFA fixed), Immunoprecipitation, Western Blot
S60-4
Unconjugated
ATP7A
Liquid
Atp7A
Synthetic peptide amino acids 42-61 (cytoplasmic C-terminus) of human Copper- transporting ATPase1
Protein G
RUO
Antibody
Monoclonal
Human, Mouse, Rat
Documents
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