Invitrogen™ ATP7B Monoclonal Antibody (L62/29), FITC

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA545523

Catalog No. PIMA545523

Description

1 μg/mL of MA5-45523 was sufficient for detection of Copper-transporting ATPase2 in 20 μg of rat brain lysate by colorimetric immunoblot analysis using Goat IgG:HRP as the secondary antibody. Detects approximately 160kDa in rat brain membrane preparations. This antibody was formerly sold as clone S62-29.

This gene is a member of the P-type cation transport ATPase family and encodes a protein with several membrane-spanning domains, an ATPase consensus sequence, a hinge domain, a phosphorylation site, and at least 2 putative copper-binding sites. This protein functions as a monomer, exporting copper out of the cells, such as the efflux of hepatic copper into the bile. Alternate transcriptional splice variants, encoding different isoforms with distinct cellular localizations, have been characterized. Mutations in this gene have been associated with Wilson disease (WD).

Specifications

• Antigen: ATP7B
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS, 9.1 mM sodium bicarbonate with 640.91 mM DMSO, 136.36 mM ethanolamine and no preservative; pH 7.4
• Gene Accession No.: P35670, Q64446, Q64535
• Gene Symbols: Atp7b
• Immunogen: Synthetic peptide amino acids 3-21 (cytoplasmic N-terminus) of human Copper-transporting ATPase2.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunohistochemistry, Immunoprecipitation, Western Blot, Immunocytochemistry
• Clone: L62/29
• Conjugate: FITC
• Gene: Atp7b
• Gene Alias: Atp7a; ATP7B; ATPase copper transporting beta; ATPase, Cu(2+)- transporting, beta polypeptide; ATPase, Cu++ transporting, beta polypeptide; ATPase, Cu++ transporting, beta polypeptide (same as Wilson disease); copper pump 2; Copper-transporting ATPase 2; Hts; PINA; PINA gene, promoter; pineal night-specific ATPase; PWD; RP11-327P2.1; RP11-327P2.3; toxic milk; tx; WC1; WD; Wilson disease-associated protein; wilson disease-associated protein homolog; Wilson protein; Wnd; WND/140 kDa
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 11979, 24218, 540
• Content And Storage: 4°C, store in dark
• Form: Liquid

Safety and Handling

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