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Invitrogen™ ATP7B Monoclonal Antibody (L62/29)
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Catalog No. PIMA527719
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100 μg
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PIMA527719 100 μg
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Catalog No. PIMA527719 Supplier Invitrogen™ Supplier No. MA527719
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Mouse Monoclonal Antibody

1 μg/mL of MA5-27719 was sufficient for detection of Copper-transporting ATPase2 in 20 μg of rat brain lysate by colorimetric immunoblot analysis using Goat IgG:HRP as the secondary antibody. Detects approximately 160kDa in rat brain membrane preparations. This antibody was formerly sold as clone S62-29.

This gene is a member of the P-type cation transport ATPase family and encodes a protein with several membrane-spanning domains, an ATPase consensus sequence, a hinge domain, a phosphorylation site, and at least 2 putative copper-binding sites. This protein functions as a monomer, exporting copper out of the cells, such as the efflux of hepatic copper into the bile. Alternate transcriptional splice variants, encoding different isoforms with distinct cellular localizations, have been characterized. Mutations in this gene have been associated with Wilson disease (WD).
TRUSTED_SUSTAINABILITY

Specifications

Antigen ATP7B
Applications Immunohistochemistry (PFA fixed), Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone L62/29
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.09% sodium azide; pH 7.4
Gene Atp7b
Gene Accession No. P35670, Q64446, Q64535
Gene Alias Atp7a; ATP7B; ATPase copper transporting beta; ATPase, Cu(2+)- transporting, beta polypeptide; ATPase, Cu++ transporting, beta polypeptide; ATPase, Cu++ transporting, beta polypeptide (same as Wilson disease); copper pump 2; Copper-transporting ATPase 2; Hts; PINA; PINA gene, promoter; pineal night-specific ATPase; PWD; RP11-327P2.1; RP11-327P2.3; toxic milk; tx; WC1; WD; Wilson disease-associated protein; wilson disease-associated protein homolog; Wilson protein; Wnd; WND/140 kDa
Gene Symbols Atp7b
Host Species Mouse
Immunogen Synthetic peptide amino acids 3-21 (cytoplasmic N-terminus) of human Copper-transporting ATPase2.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11979, 24218, 540
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG1
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