Invitrogen™ ATP7B Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5120938

Catalog No. PIPA5120938

Description

Positive test controls include: BT-474, HL-60, Mouse liver. The target is usually found in the following locations: Cytoplasm, Golgi apparatus, Golgi apparatus membrane, Mitochondrion, Multi-pass membrane protein, Multi-pass membrane protein, trans-Golgi network membrane. Immunogen sequence: SSVSVVLSSL QLKCYKKPDL ERYEAQAHGH MKPLTASQVS VHIGMDDRWR DSPRATPWDQ VSYVSQVSLS SLTSDKPSRH SAAADDDGDK WSLLLNGRDE E.

This gene is a member of the P-type cation transport ATPase family and encodes a protein with several membrane-spanning domains, an ATPase consensus sequence, a hinge domain, a phosphorylation site, and at least 2 putative copper-binding sites. This protein functions as a monomer, exporting copper out of the cells, such as the efflux of hepatic copper into the bile. Alternate transcriptional splice variants, encoding different isoforms with distinct cellular localizations, have been characterized. Mutations in this gene have been associated with Wilson disease (WD).

Specifications

• Antigen: ATP7B
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Atp7b
• Gene Alias: Atp7a; ATP7B; ATPase copper transporting beta; ATPase, Cu(2+)- transporting, beta polypeptide; ATPase, Cu++ transporting, beta polypeptide; ATPase, Cu++ transporting, beta polypeptide (same as Wilson disease); copper pump 2; Copper-transporting ATPase 2; Hts; PINA; PINA gene, promoter; pineal night-specific ATPase; PWD; RP11-327P2.1; RP11-327P2.3; toxic milk; tx; WC1; WD; Wilson disease-associated protein; wilson disease-associated protein homolog; Wilson protein; Wnd; WND/140 kDa
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 24218, 540
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1.73 mg/mL
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
• Gene Accession No.: P35670, Q64535
• Gene Symbols: Atp7b
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1251-1351 of human ATP7B (NP_0012301111).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov