Invitrogen™ ATP8A2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA558990

Catalog No. PIPA558990

Description

Immunogen sequence: MLNGAGLDKA LKMSLPRRSR IRSSVGPVRS SLGYKKAEDE MSRATSVGDQ LEAPARTIYL NQPHLNKFRD NQISTAKYSV LTF Highest antigen sequence identity to the following orthologs: Mouse - 76%, Rat - 66%.

Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. Reconstituted to liposomes, the ATP8A2:TMEM30A flippase complex predomiminantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE). Proposed to function in the generation and maintenance of phospholipid asymmetry in photoreceptor disk membranes and neuronal axon membranes. May be involved in vesicle trafficking in neuronal cells. Involved in regulation of neurite outgrowth; acting in synergy with TMEM30A. Required for normal visual and auditory function; involved in photoreceptor and inner ear spiral ganglion cell survival.

Specifications

• Antigen: ATP8A2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ATP8A2
• Gene Alias: ATP; ATP8A2; ATPase class I type 8A member 2; ATPase phospholipid transporting 8A2; ATPase, aminophospholipid transporter, class I, type 8A, member 2; ATPase, aminophospholipid transporter-like, class I, type 8A, member 2; ATPIB; CAMRQ4; IB; ML-1; P4-ATPase flippase complex alpha subunit ATP8A2; Phospholipid-transporting ATPase IB; probable phospholipid-transporting ATPase IB
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 51761
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.3 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9NTI2
• Gene Symbols: ATP8A2
• Immunogen: Recombinant protein corresponding to Human ATP8A2. Recombinant protein control fragment (Product #RP-97955).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG