Invitrogen™ ATP8A2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA524417

Catalog No. PIPA524417

Description

ATP8A2 Polyclonal Antibody for Western Blot, Flow

Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. Reconstituted to liposomes, the ATP8A2:TMEM30A flippase complex predomiminantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE). Proposed to function in the generation and maintenance of phospholipid asymmetry in photoreceptor disk membranes and neuronal axon membranes. May be involved in vesicle trafficking in neuronal cells. Involved in regulation of neurite outgrowth; acting in synergy with TMEM30A. Required for normal visual and auditory function; involved in photoreceptor and inner ear spiral ganglion cell survival.

Specifications

• Antigen: ATP8A2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ATP8A2
• Gene Alias: ATP; ATP8A2; ATPase class I type 8A member 2; ATPase phospholipid transporting 8A2; ATPase, aminophospholipid transporter, class I, type 8A, member 2; ATPase, aminophospholipid transporter-like, class I, type 8A, member 2; ATPIB; CAMRQ4; IB; ML-1; P4-ATPase flippase complex alpha subunit ATP8A2; Phospholipid-transporting ATPase IB; probable phospholipid-transporting ATPase IB
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography, Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 51761
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Flow Cytometry, Western Blot
• Concentration: 0.45 mg/mL
• Formulation: PBS with 0.09% sodium azide; pH 7.4
• Gene Accession No.: Q9NTI2
• Gene Symbols: ATP8A2
• Immunogen: KLH conjugated synthetic peptide between 293-322 amino acids from the N-terminal region of human ATP8A2.
• Quantity: 400 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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