Invitrogen™ Atpalpha Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA532093

Catalog No. PIPA532093

Description

Recommended positive controls: Drosophila lysate. Predicted reactivity: Drosophila (100%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The ATPa, or ATPalpha gene, encodes a subunit of the Na+/K+ ATPase enzyme, which is crucial for maintaining cellular ion gradients by actively transporting Na+ out of cells and K+ into cells. This gene is essential in various organisms, including Drosophila melanogaster (fruit fly). Mutations in the ATPalpha gene can lead to significant developmental and physiological abnormalities, such as neurodegeneration, altered longevity, and myodegeneration. One of its critical roles is in neuromuscular functioning, where it affects locomotor activity, with mutations causing conditional bang-sensitive or temperature-sensitive paralysis. Additionally, ATPalpha mutations disrupt the formation and function of septate junctions in Drosophila, structures analogous to vertebrate tight junctions, further underscoring its role in maintaining cellular integrity and signal transduction.

Specifications

• Antigen: Atpalpha
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Atpalpha
• Gene Alias: (Na[+] + K[+])-ATPase alpha-subunit; (Na[+],K[+])ATPase alpha subunit; (Na[+]/k[+])-ATPase; alpha-ATPase; alpha-subunit of ATPase; Atp; Atp a; ATPa; atpalpha; ATP-alpha; Atpalpha-PA; Atpalpha-PB; Atpalpha-PC; Atpalpha-PD; Atpalpha-PE; Atpalpha-PF; Atpalpha-PG; Atpalpha-PH; Atpalpha-PI; Atpalpha-PJ; Atpalpha-PK; ATPase alpha; ATPase alpha subunit; ATPBagr; CG5670; CG5670-PA; CG5670-PB; CG5670-PC; CG5670-PD; CG5670-PE; CG5670-PF; CG5670-PG; CG5670-PH; CG5670-PI; CG5670-PJ; CG5670-PK; Da-47; Dmel\CG5670; Dmel_CG5670; dnATPase; JY; K ATPase; K[+] -ATPase; K[+]-ATPase; K[+]-ATPase alpha subunit; K[+]-ATPase alpha-subunit; K-ATPase; l(3)01164; l(3)01453; l(3)04492; l(3)j3B2; l(3)j3B7; l(3)j6A4; l(3)rM454; l(3)ry136; Na; Na pump alpha subunit; Na(+)/K(+) ATPase alpha subunit; Na, K ATPase a subunit; Na,K ATPase; Na,K ATPase alpha subunit; Na,K-ATPase; Na,K-ATPase alpha; Na,K-ATPase alpha subunit; Na,K-ATPase alpha-subunit; Na/K ATPase; Na/K-ATPase; Na/K-ATPase alpha-subunit; Na[ +], K[ +] -ATPase; Na[+]; Na[+] pump alpha subunit; Na[+], K[+] ATPase alpha; Na[+],K[+] ATPase alpha subunit; Na[+],K[+]-ATPase alpha subunit; Na[+]/K[+] ATPase; Na[+]/K[+] ATPase (alpha subunit); Na[+]/K[+] ATPase alpha subunit; Na[+]/K[+]ATPase; Na[+]/K[+]-ATPase; Na[+]K[+] ATPase; Na[+]-K[+] ATPase; Na[+]K[+] ATPase alpha subunit; Na[+]K[+]ATPase; Na[+]K[+]-ATPase; Na[+]-K[+]-ATPase alpha[[5]]-subunit; Na+,K+ ATPase alpha-subunit; Na+/K+ ATPase alpha subunit; Na+/K+-ATPase; Na+-K+-ATPase; NaK; NaK ATPase; NaK-ATPase; Na-p; NKA; sodium pump alpha subunit; sodium pump alpha-subunit; Sodium pump subunit alpha; sodium/potassium transporting ATPase alpha; Sodium/potassium-transporting ATPase subunit alpha
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 48971
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: P13607
• Gene Symbols: Atpalpha
• Immunogen: Recombinant protein encompassing a sequence within the center region of Drosophila Atpalpha. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Drosophila, Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov