Invitrogen™ ATRX Monoclonal Antibody (GT4212)

Catalog No.	Quantity
PIMA527732	100 μL

Catalog No. PIMA527732 Supplier Invitrogen™ Supplier No. MA527732

Description

Mouse Monoclonal Antibody

Positive Control: 293T, Neuro2A, C8D30, BCL-1 Predicted Reactivity: Chimpanzee (100%) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

ATRX encodes a protein that contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.

Specifications

• Antigen: ATRX
• Applications: Western Blot, Immunocytochemistry
• Classification: Monoclonal
• Clone: GT4212
• Concentration: 1.0 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with no preservative
• Gene: ATRX
• Gene Accession No.: P46100, Q61687
• Gene Alias: 4833408C14Rik; AI447451; alpha thalassemia/mental retardation syndrome (X-linked); alpha thalassemia/mental retardation syndrome X-linked; alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae); alpha thalassemia/mental retardation syndrome X-linked homolog; alpha thalassemia/mental retardation syndrome X-linked homolog (human); ATP-dependent helicase ATRX; ATR2; ATRX; ATRX, chromatin remodeler; DNA dependent ATPase and helicase; DXHXS6677E; helicase 2; helicase 2, X-linked; helicase II; heterochromatin protein 2; HP1 alpha-interacting protein; Hp1bp2; Hp1bp38; HP1-BP38; HP1-BP38 protein; JMS; mental retardation, X-linked 52; MRX52; MRXHF1; MRXS3; pABP-2; Rad54; RAD54L; RP5-875J14.1; SFM1; SHS; transcriptional regulator ATRX; XH2; X-linked helicase II; X-linked nuclear protein; XNP; Zinc finger helicase; Znf-HX
• Gene Symbols: ATRX
• Host Species: Mouse
• Immunogen: Recombinant protein encompassing a sequence within the C-terminus region of human ATRX. The exact sequence is proprietary.
• Purification Method: Protein G
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 22589, 546
• Target Species: Human, Mouse
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1