ATX3/ATXN3 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-172-8792	Proteintech Group Inc 135051AP150UL	150 μL

Description

Machado-Joseph disease is an autosomal domit neurologic disorder, and is now known to be the same as previously described spinocerebellar ataxia-3. MJD protein (Ataxin-3) contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 13-36 to 68-79 is the cause of Machado-Joseph disease. There is a negative correlation between the age of onset and CAG repeat numbers. This protein interacts with key regulators (CBP, p300 and PCAF) of transcription and represses transcription, and also acts as a histone-binding protein that regulates transcription. MJD is a deubiquitinating enzyme.

Specifications

• Antigen: ATX3/ATXN3
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Mouse, Rat
• Gene Accession No.: O35815, P54252, Q9CVD2
• Gene ID (Entrez): 110616, 4287, 60331
• Immunogen: ATX3,ATXN3 Fusion Protein Ag4341
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: ATXN3

• Concentration: 0.37 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Alias: AT3, ataxin 3, ATX3, ATXN3, JOS, MJD, MJD1, SCA3
• Gene Symbols: Atxn3
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody