Invitrogen™ ATXN10 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5120890

Catalog No. PIPA5120890

Description

Positive test controls include: HeLa, SKOV3, LO2, HL-60, 293T, Mouse heart, Mouse kidney, Mouse liver, Rat testis. The target is usually found in the following locations: Cytoplasm, perinuclear region. Immunogen sequence: ETTNIFSNCG CVRAEGDISN VANGFKSHLI RLIGNLCYKN KDNQDKVNEL DGIPLILDNC NISDSNPFLT QWVIYAIRNL TEDNSQNQDL IAKMEEQGLA DASLLKKVGF EVEKKGEKLI LKSTRDTPKP.

The autosomal dominant cerebellar ataxias (ADCAs) are a clinically and genetically heterogeneous group of disorders characterized by ataxia, dysarthria, dysmetria, and intention tremor. All ADCAs involve some degree of cerebellar dysfunction and a varying degree of signs from other components of the nervous system. A commonly accepted clinical classification (Harding, 1993) divides ADCAs into 3 different groups based on the presence or absence of associated symptoms such as brainstem signs or retinopathy. The presence of pyramidal and extrapyramidal symptoms and ophthalmoplegia makes the diagnosis of ADCA I, the presence of retinopathy points to ADCA II, and the absence of associated signs to ADCA III. Genetic linkage and molecular analyses revealed that ADCAs are genetically heterogeneous even within the various subtypes.

Specifications

• Antigen: ATXN10
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ATXN10
• Gene Alias: AI325283; ataxin 10; ataxin 10 homolog; ataxin-10; ATXN10; Brain protein E46; brain protein E46 homolog; C77170; E46; E46L; HUMEEP; Neuronal beta-catenin-like protein; Sca10; spinocerebellar ataxia 10; spinocerebellar ataxia 10 homolog; spinocerebellar ataxia type 10 protein; Spinocerebellar ataxia type 10 protein homolog; TEG-169; testis expressed gene 169; Tex169
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 170821, 25814, 54138
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot, Immunocytochemistry
• Concentration: 1.46 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P28658, Q9ER24, Q9UBB4
• Gene Symbols: ATXN10
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 346-475 of human ATXN10 (NP_037368.1).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG