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Invitrogen™ ATXN7L2 Polyclonal Antibody
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Catalog No. PIPA556270
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100 μL
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PIPA556270 100 μL
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Catalog No. PIPA556270 Supplier Invitrogen™ Supplier No. PA556270
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: IHSVHQRREV QGRAKDFDVL VAELKANSRK GESPKEKSPG RKEQVLERPS QELPSSVQVV AAVAAPSSTF SVRAKQTYP Highest antigen sequence identity to the following orthologs: Mouse - 81%, Rat - 81%.

SCA7 is an autosomal dominant neurodegenerative disorder characterized by ataxia and selective neuronal cell loss caused by the expansion of a translated CAG repeat encoding a polyglutamine tract in ataxin-7, which is the SCA7 gene product. Ataxin-7 is a nuclear protein that is expressed within neurons both affected and unaffected in SCA7 pathology with subcellular localization being variable depending upon the neuronal subtype. Polyglutamine expanded in ataxin-7 may carry out its pathogenic effects in the nucleus by altering the matrix-associated nuclear structure and/or by disrupting nucleolar function.ATXN7L2 (Ataxin-7-like protein 2) is a 722 amino acid protein that contains a SCA7 domain, which is highly conserved through all members of the ATXN7 gene family. The gene encoding ATXN7L2 maps to human chromosome 1, the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ATXN7L2
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene ATXN7L2
Gene Accession No. Q5T6C5
Gene Alias 2610528J18Rik; ataxin 7 like 2; ataxin 7-like 1; ataxin 7-like 2; ataxin-7-like protein 2; ATXN7L2; mFLJ00381 protein; RGD1307047
Gene Symbols ATXN7L2
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human ATXN7L2. Recombinant protein control fragment (Product #RP-94399).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 127002
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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