Invitrogen™ ATXN7L2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA556270

Catalog No. PIPA556270

Description

Immunogen sequence: IHSVHQRREV QGRAKDFDVL VAELKANSRK GESPKEKSPG RKEQVLERPS QELPSSVQVV AAVAAPSSTF SVRAKQTYP Highest antigen sequence identity to the following orthologs: Mouse - 81%, Rat - 81%.

SCA7 is an autosomal dominant neurodegenerative disorder characterized by ataxia and selective neuronal cell loss caused by the expansion of a translated CAG repeat encoding a polyglutamine tract in ataxin-7, which is the SCA7 gene product. Ataxin-7 is a nuclear protein that is expressed within neurons both affected and unaffected in SCA7 pathology with subcellular localization being variable depending upon the neuronal subtype. Polyglutamine expanded in ataxin-7 may carry out its pathogenic effects in the nucleus by altering the matrix-associated nuclear structure and/or by disrupting nucleolar function.ATXN7L2 (Ataxin-7-like protein 2) is a 722 amino acid protein that contains a SCA7 domain, which is highly conserved through all members of the ATXN7 gene family. The gene encoding ATXN7L2 maps to human chromosome 1, the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome.

Specifications

• Antigen: ATXN7L2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ATXN7L2
• Gene Alias: 2610528J18Rik; ataxin 7 like 2; ataxin 7-like 1; ataxin 7-like 2; ataxin-7-like protein 2; ATXN7L2; mFLJ00381 protein; RGD1307047
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 127002
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q5T6C5
• Gene Symbols: ATXN7L2
• Immunogen: Recombinant protein corresponding to Human ATXN7L2. Recombinant protein control fragment (Product #RP-94399).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG