Invitrogen™ ATXN7L3 Polyclonal Antibody

Catalog No.	Quantity
PIPA5103624	100 μL

Catalog No. PIPA5103624

Supplier: Invitrogen™ PA5103624

Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total ATXN7L3.

Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B (PubMed:18206972, PubMed:21746879). The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and ENY2 into the SAGA complex (PubMed:18206972). Regulates H2B monoubiquitination (H2Bub1) levels. Affects subcellular distribution of ENY2, USP22 and ATXN7L3B (PubMed:27601583). [UniProt].

Specifications

• Antigen: ATXN7L3
• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene: ATXN7L3
• Gene Accession No.: A2AWT3, Q14CW9
• Gene Alias: AT7L3; ataxin 7 like 3; ataxin 7-like 3; ataxin-7-like protein 3; ATXN7L3; DKFZp761G2113; E030022H21Rik; SAGA-associated factor 11 homolog
• Gene Symbols: ATXN7L3
• Host Species: Rabbit
• Immunogen: A synthesized peptide derived from human ATXN7L3(Accession Q14CW9), corresponding to amino acid residues S112-N162.
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 217218, 56970
• Target Species: Human, Mouse
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG