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Invitrogen™ ATXN7L3B Polyclonal Antibody
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Catalog No. PIPA566027
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PIPA566027 100 μL
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Catalog No. PIPA566027 Supplier Invitrogen™ Supplier No. PA566027
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: VKCGYFYLEFA ETGSVKDFGI QPVEDKGACR LPLCSLPGEP GNGPDQQLQR SPPEFQ Highest antigen sequence identity to the following orthologs - mouse 89%, rat 93%.

By binding to ENY2, interferes with the nuclear functions of the deubiquitinase (DUB) module of the SAGA complex which consists of ENY2, ATXN7, ATXN7L3 and the histone deubiquitinating component USP22. Affects USP22 DUB activity toward histones indirectly by changing the subcellular distribution of ENY2 and altering ENY2 availability for ATXN7L3 interaction. Regulates H2B monoubiquitination (H2Bub1) levels through cytoplasmic sequestration of ENY2 resulting in loss of nuclear ENY2-ATXN7L3 association which destabilizes ATXN7L3. Affects protein expression levels of ENY2 and ATXN7L3.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ATXN7L3B
Applications Immunocytochemistry
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene ATXN7L3B
Gene Accession No. Q96GX2
Gene Alias 4921506J03Rik; 6230409E21Rik; AI315132; ataxin 7 like 3B; ataxin 7-like 3B; Ataxin-7-like protein 3B; ATXN7L3B; ENSMUSG00000074747; lnc-SCA7; putative ataxin-7-like protein 3B; putative ataxin-7-like protein 3-like protein
Gene Symbols ATXN7L3B
Host Species Rabbit
Immunogen Recombinant Human ATXN7L3B. Recombinant protein control fragment (Product #RP-106717).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 552889
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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