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Invitrogen™ AUH Polyclonal Antibody
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Catalog No. PIPA552067
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PIPA552067 100 μL
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Catalog No. PIPA552067 Supplier Invitrogen™ Supplier No. PA552067
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: SAWLCPGLRL PGSLAGRRAG PAIWAQGWVP AAGGPAPKRG YSSEMKTEDE LRVRHLEEEN RGIVVLGINR AYGKNSLSKN LIKMLSKAVD ALKSDKK Highest antigen sequence identity to the following orthologs: Mouse - 70%, Rat - 67%.

The methylglutaconyl-CoA hydratase, mitochondrial protein binds to the AU-rich element (ARE), a common element found in the 3' UTR of rapidly decaying mRNA such as c-fos, c-myc and granulocyte/ macrophage colony stimulating factor. ARE elements are involved in directing RNA to rapid degradation and deadenylation. AUH is also homologous to enol-CoA hydratase, an enzyme involved in fatty acid degradation, and has been shown to have intrinsic hydratase enzymatic activity. AUH is thus a bifunctional chimera between RNA binding and metabolic enzyme activity. A possible subcellular localization in the mitochondria has been demonstrated for the mouse homolog of this protein which shares 92% identity with the human protein. It has been suggested that AUH may have a novel role as a mitochondrial located AU-binding protein. Human AUH is expressed as a single mRNA species of 1.8 kb, and translated as a 40- kDa precursor protein which is subsequently processed to a 32- kDa mature form.
TRUSTED_SUSTAINABILITY

Specifications

Antigen AUH
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene AUH
Gene Accession No. Q13825
Gene Alias 3-methylglutaconyl-CoA hydratase; AU RNA binding methylglutaconyl-CoA hydratase; AU RNA binding protein/enoyl-CoA hydratase; AU RNA binding protein/enoyl-coenzyme A hydratase; AU RNA-binding protein/enoyl-Coenzyme A hydratase; AU-binding enoyl-CoA hydratase; AU-binding protein/enoyl-CoA hydratase; Auh; AU-specific RNA-binding enoyl-CoA hydratase; C77140; Itaconyl-CoA hydratase; Methylglutaconyl-CoA hydratase, mitochondrial; muAUH; W91705
Gene Symbols AUH
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human AUH. Recombinant protein control fragment (Product #RP-102313).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 549
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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