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Invitrogen™ Aurora B Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA585633
Description
Keep as concentrated solution. Predicted reactivity: Pig (89%), Bovine (90%). Positive Control: HeLa, HeLa (100 ng/ml Nocodazole, 24hr), 293T transfected with Aurora B. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
The Aurora kinases associate with microtubules during chromosome movement and segregation. AURKB (Aurora B) localizes to microtubules near kinetochores, specifically to the specialized microtubules called K-fibers. This complex functions in chromosome alignment and separation, histone modification, and cytokinesis. CPC also includes three non-enzymatic subunits known as the inner centromere protein (INCENP), survivin, and borealin, which determine the activity, localization, stability, and possibly even the substrate specificity of AurB. Two CPCs exist during mitosis: one containing all four members and another consisting of INCENP and AurB. Quaternary CPC functions during chromosome alignment and cytokinesis, whereas the INCENP-AurB complex may be responsible for modifying histone H3. AurB is overexpressed in a number of tumours, including primary breast and colon tumour samples. Its expression in tumours seems to be linked with Aurora-A kinase, suggesting a feedback mechanism between the two proteins.
Specifications
Aurora B | |
Polyclonal | |
Unconjugated | |
AURKB | |
Aik2; AIM1; AIM-1; AIRK2; AL022959; ARK2; ARK-2; AurB; AURKB; aurkb-sv1; aurkb-sv2; aurora 1; aurora- and IPL1-like midbody-associated protein 1; aurora B; aurora kinase B; aurora kinase B-Sv1; aurora kinase B-Sv2; aurora/IPL1-related kinase 2; aurora-1; aurora-B; aurora-related kinase 2; IPL1; PPP1R48; protein phosphatase 1, regulatory subunit 48; serine/threonine kinase; serine/threonine kinase 12; serine/threonine kinase 5; Serine/threonine-protein kinase 12; Serine/threonine-protein kinase 5; serine/threonine-protein kinase aurora-B; STK1; STK-1; Stk12; STK12; AIK2; AIM1; ARK2; IPL1; AIM-1; STK5 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
9212 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Western Blot | |
0.81 mg/mL | |
PBS with 20% glycerol and 0.025% ProClin 300; pH 7 | |
Q96GD4 | |
AURKB | |
Recombinant protein encompassing a sequence within the N-terminus region of human Aurora B. | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
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