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Aurora B Polyclonal Antibody, Active Motif™
SDP

Catalog No. 501993975
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200 μL
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50-199-3975 200 μL
50-199-3976 10 μL
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Catalog No. 50-199-3975 Supplier Active Motif Supplier No. 39261
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Description

Rabbit Polyclonal Antibody

Aurora-B kinase (AurB) is a serine/threonine kinase which is the enzymatic core of the Chromosomal Passenger Complex (CPC). This complex functions in chromosome alignment and separation, histone modification, and cytokinesis. CPC also includes three non-enzymatic subunits known as the inner centromere protein (INCENP), survivin, and borealin, which determine the activity, localization, stability, and possibly even the substrate specificity of AurB. Two CPCs exist during mitosis: one containing all four members and another consisting of INCENP and AurB. Quaternary CPC functions during chromosome alignment and cytokinesis, whereas the INCENP-AurB complex may be responsible for modifying histone H3. AurB is overexpressed in a number of tumours, including primary breast and colon tumour samples. Its expression in tumours seems to be linked with Aurora-A kinase, suggesting a feedback mechanism between the two proteins.

Specifications

Antigen Aurora B
Applications Immunocytochemistry, Immunofluorescence, Western Blot
Classification Polyclonal
Concentration Conc. Not Determined
Conjugate Unconjugated
Formulation whole serum with 30% glycerol and 0.035% sodium azide; pH
Gene AURKB
Gene Accession No. O70126, Q96GD4
Gene Alias AIE2; AIK1; Aik2; AIK3; AIM1; AIM-1; AIRK2; AIRK3; AL022959; Ark2; ARK-2; ARK3; ARK-3; AurB; Aurkb; aurkb-sv1; aurkb-sv2; AURKC; Aurora 1; Aurora 3; Aurora- and IPL1-like midbody-associated protein 1; aurora B; Aurora kinase B; aurora kinase B; serine/threonine-protein kinase 12; aurora kinase B-Sv1; aurora kinase B-Sv2; Aurora kinase C; Aurora/IPL1-related kinase 2; aurora-1; aurora-B; aurora-related kinase 2; BOS_18918; EC 2.7.11.1; IPL1; NP_004208; PPP1R48; protein phosphatase 1, regulatory subunit 48; serine/threonine kinase 12; serine/threonine kinase 5; Serine/threonine-protein kinase 12; Serine/threonine-protein kinase 5; Serine/threonine-protein kinase aurora-B; STK1; STK-1; STK12; STK13; STK5
Gene Symbols AURKB
Host Species Rabbit
Immunogen This Aurora B antibody was raised against a peptide including the C-terminus of human Aurora B.
Quantity 200 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 20877, 9212
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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