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Tocris Bioscience™ Auxinole
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Catalog No. 789450
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78-945-0 50 mg
78-941-0 10 mg
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Catalog No. 78-945-0 Supplier Tocris Bioscience™ Supplier No. 7894/50
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Description

Auxin antagonist of TIR1/AFB receptors; also OsTIR1 inhibitor in auxin-inducible degron (AID) system

Auxinole is an auxin antagonist of TIR1/AFB receptors. Binds to TIR1 to block the formation of the TIR1-IAA-Aux/IAA complex and inhibit auxin-responsive gene expression. Auxinole competitively inhibits various auxin responses in planta. Auxinole also inhibits OsTIR1 that suppresses leaky degradation of degron-fused proteins. Can be used as a control compound with 5-Ph-IAA (Cat. No. 7392) in the AID2 degron system to switch off degradation.

Specifications

Chemical Name or Material α-[2-(2,4-Dimethylphenyl)-2-oxoethyl]-1H-indole-3-acetic acid
CAS 86445-22-9
Quantity 50 mg
Target Molecular Glues
Molecular Formula C20H19NO3
Purity 98%
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