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Invitrogen™ AVEN Polyclonal Antibody
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Catalog No. PIPA520287
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100 μg
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Catalog No. Quantity
PIPA520287 100 μg
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Catalog No. PIPA520287 Supplier Invitrogen™ Supplier No. PA520287
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Description

Rabbit Polyclonal Antibody

Despite its predicted molecular weight, Aven often migrates at 55kDa in SDS-PAGE. A suggested positive control is Raji cell lysate. PA5-20287 can be used with blocking peptide PEP-0405.

Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Aven is a recently discovered protein that blocks apoptosis induced by Apaf-1 and caspase-9. It is thought that Aven functions by binding to Bcl-xL, an antiapoptotic member of the Bcl-2 family, and to Apaf-1, possibly interfering with the ability of Apaf-1 to self-associate, suggesting that Aven impedes Apaf-1-mediated caspase activation. Higher levels of Aven mRNA are seen in patients with acute leukemia than in control patients, suggesting that Aven may be useful as a prognostic indicator in leukemia patients.
TRUSTED_SUSTAINABILITY

Specifications

Antigen AVEN
Applications Immunohistochemistry, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene AVEN
Gene Accession No. Q9D9K3, Q9NQS1
Gene Alias 1700013A01Rik; 1700056A21Rik; apoptosis and caspase activation inhibitor; apoptosis, caspase activation inhibitor; AVEN; Cell death regulator Aven; mAven-L; mAven-S; PDCD12; programmed cell death 12
Gene Symbols AVEN
Host Species Rabbit
Immunogen A 14 amino acid peptide from near the carboxy terminus of human Aven.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 311299, 57099, 74268
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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