Invitrogen™ AVPR1B Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA575375

Catalog No. PIPA575375

Description

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Vasopressin V1B receptor expression has been documented in the pituitary, pituitary tumors, pheochromocytoma, breast cancer, and small-cell lung carcinomas. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This turn-off activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.

Specifications

• Antigen: AVPR1B
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: AVPR1B
• Gene Alias: Antidiuretic hormone receptor 1b; arginine vasopressin receptor 1B; arginine vasopressin receptor 3; arginine vasopressin receptor V3; arginine vasopressin type 1b receptor; AVP receptor V3; AVPR V1b; AVPR V3; Avpr1b; AVPR3; pituitary vasopressin receptor 3; V1b receptor; V1bR; V3/V1b; V3/V1b pituitary vasopressin receptor; vasopressin V1b receptor; Vasopressin V3 receptor; VIBR; VPR3
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 26361, 29462, 553
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P47901, P48974, Q9WU02
• Gene Symbols: AVPR1B
• Immunogen: Synthetic peptide corresponding to amino acids 300-350 of Human V1b Receptor.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov