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Invitrogen™ AVPR1B Polyclonal Antibody
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Catalog No. PIPA5106854
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100 μL
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PIPA5106854 100 μL
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Catalog No. PIPA5106854 Supplier Invitrogen™ Supplier No. PA5106854
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total AVPR1B.

Vasopressin V1B receptor expression has been documented in the pituitary, pituitary tumors, pheochromocytoma, breast cancer, and small-cell lung carcinomas. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This turn-off activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.
TRUSTED_SUSTAINABILITY

Specifications

Antigen AVPR1B
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene AVPR1B
Gene Accession No. P47901
Gene Alias Antidiuretic hormone receptor 1b; arginine vasopressin receptor 1B; arginine vasopressin receptor 3; arginine vasopressin receptor V3; arginine vasopressin type 1b receptor; AVP receptor V3; AVPR V1b; AVPR V3; Avpr1b; AVPR3; pituitary vasopressin receptor 3; V1b receptor; V1bR; V3/V1b; V3/V1b pituitary vasopressin receptor; vasopressin V1b receptor; Vasopressin V3 receptor; VIBR; VPR3
Gene Symbols AVPR1B
Host Species Rabbit
Immunogen A synthesized peptide derived from human AVPR1B(Accession P47901), corresponding to amino acid residues T283-C333.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 553
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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WARNING: Cancer - www.P65Warnings.ca.gov
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