Invitrogen™ AVPR1B Polyclonal Antibody

Catalog No.	Quantity
PIPA570604	100 μL

Catalog No. PIPA570604 Supplier Invitrogen™ Supplier No. PA570604

Description

Rabbit Polyclonal Antibody

This target displays homology in the following species: Cow: 93%; Dog: 100%; Guinea Pig: 93%; Horse: 75%; Human: 100%; Mouse: 86%; Rabbit: 86%; Rat: 86%; Sheep: 93%.

Vasopressin V1B receptor expression has been documented in the pituitary, pituitary tumors, pheochromocytoma, breast cancer, and small-cell lung carcinomas. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This turn-off activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.

Specifications

• Antigen: AVPR1B
• Applications: Western Blot
• Classification: Polyclonal
• Concentration: 0.5 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 2% sucrose and 0.09% sodium azide
• Gene: AVPR1B
• Gene Accession No.: P47901
• Gene Alias: Antidiuretic hormone receptor 1b; arginine vasopressin receptor 1B; arginine vasopressin receptor 3; arginine vasopressin receptor V3; arginine vasopressin type 1b receptor; AVP receptor V3; AVPR V1b; AVPR V3; Avpr1b; AVPR3; pituitary vasopressin receptor 3; V1b receptor; V1bR; V3/V1b; V3/V1b pituitary vasopressin receptor; vasopressin V1b receptor; Vasopressin V3 receptor; VIBR; VPR3
• Gene Symbols: AVPR1B
• Host Species: Rabbit
• Immunogen: synthetic peptide directed towards the middle region of human V1b Receptor (aa 271-320).
• Purification Method: Affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 553
• Target Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov