AVPR1B Rabbit anti-Human, Polyclonal, Proteintech

Catalog No.	Quantity
50-173-6014	150 μL

Catalog No. 50-173-6014 Supplier Proteintech Group Inc Supplier No. 551421AP150UL

Description

Rabbit Polyclonal Antibody

Vasopressin V1B receptor expression has been documented in the pituitary, pituitary tumors, pheochromocytoma, breast cancer, and small-cell lung carcinomas. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This turn-off activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.

Specifications

• Antigen: AVPR1B
• Applications: Immunohistochemistry (Paraffin)
• Classification: Polyclonal
• Concentration: 0.2 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene: AVPR1B
• Gene Accession No.: P47901
• Gene Alias: AVPR V1b, AVPR V3, AVPR1B, AVPR3, V1bR, Vasopressin V1b receptor, Vasopressin V3 receptor, VPR3
• Gene Symbols: AVPR1B
• Host Species: Rabbit
• Immunogen: Peptide
• Purification Method: Antigen Affinity Chromatography
• Quantity: 150 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 553
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG