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Invitrogen™ AVPR2 Polyclonal Antibody
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Catalog No. PIPA575409
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100 μL
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PIPA575409 100 μL
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Catalog No. PIPA575409 Supplier Invitrogen™ Supplier No. PA575409
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Description

Rabbit Polyclonal Antibody

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Avpr2 is a precursor protein consisting of arginine vasopressin and two associated proteins, neurophysin 2 and a glycopeptide, copeptin. Arginine vasopressin is a posterior pituitary hormone which is synthesized in the supraoptic nucleus and paraventricular nucleus of the hypothalamus. Along with its carrier protein, neurophysin 2, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis where it is either stored or secreted into the bloodstream. The precursor is thought to be activated while it is being transported along the axon to the posterior pituitary. Arginine vasopressin acts as a growth factor by enhancing pH regulation through acid-base transport systems. Avpr2 has a direct antidiuretic action on the kidney, and also causes vasoconstriction of the peripheral vessels. Avpr2 can contract smooth muscle during parturition and lactation. Avpr2 is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions. The activity of Avpr2 is mediated by G proteins which activate adenylate cyclase.
TRUSTED_SUSTAINABILITY

Specifications

Antigen AVPR2
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
Gene AVPR2
Gene Accession No. O88721, P30518, Q00788
Gene Alias ADHR; antidiuretic hormone receptor; arginine vasopressin receptor 2; Avp2r; AVPR V2; AVPR2; DI1; DIR; DIR3; MGC126533; MGC138386; ND1; NDI; nephrogenic diabetes insipidus; renal-type arginine vasopressin receptor; V2R; V2-renal V2R; Vasopressin receptor V2; vasopressin V2 receptor; VPV2R
Gene Symbols AVPR2
Host Species Rabbit
Immunogen Synthetic peptide corresponding to amino acids 80-130 of Human AVPR2.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12000, 25108, 554
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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