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Tocris Bioscience™ AX 15836, > 98%

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Quantity:
10 mg
Description
Potent and selective ERK5 inhibitor (IC50 = 8 nM). Exhibits >1,000-fold selectivity for ERK5 over a panel of over 200 kinases. Also exhibits selectivity over bromodomain BRD4 (Kd = 3,600 nM). Increases vomocytosis in human macrophages in vitro, as well as in an in vivo zebrafish model of cryptococcal disease, reducing spread of infection.
Specifications
Specifications
Quantity | 10 mg |
Solubility | Soluble to 100mM in 1eq. HCl and to 100mM in DMSO |
Formula Weight | 648.78 |
Purity | >98% |
Molecular Weight (g/mol) | 648.78 |
Chemical Name or Material | 5,11-Dihydro-2-[[2-ethoxy-4-[[4-(4-methyl-1-piperazinyl)-1-piperidinyl]carbonyl]phenyl]amino]-5-meth |
Safety and Handling
Recommended Storage | Store at -20°C |
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