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Tocris Bioscience™ AX 15836, > 98%
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Catalog No. 584310
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10 mg
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Catalog No. Quantity
58-431-0 10 mg
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Catalog No. 58-431-0 Supplier Tocris Bioscience™ Supplier No. 5843/10
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Description

Potent and selective ERK5 inhibitor

Potent and selective ERK5 inhibitor (IC50 = 8 nM). Exhibits >1,000-fold selectivity for ERK5 over a panel of over 200 kinases. Also exhibits selectivity over bromodomain BRD4 (Kd = 3,600 nM). Increases vomocytosis in human macrophages in vitro, as well as in an in vivo zebrafish model of cryptococcal disease, reducing spread of infection.

Chemical Identifiers

CAS 2035509-96-5
Molecular Formula C32H40N8O5S

Specifications

Quantity 10 mg
Solubility Soluble to 100mM in 1eq. HCl and to 100mM in DMSO
Formula Weight 648.78
Purity >98%
Molecular Weight (g/mol) 648.78
Chemical Name or Material 5,11-Dihydro-2-[[2-ethoxy-4-[[4-(4-methyl-1-piperazinyl)-1-piperidinyl]carbonyl]phenyl]amino]-5-meth

Safety and Handling

Recommended Storage Store at -20°C
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